One of the most frequent cannabinoids present in the cannabis plant, along with cannabidiol (CBD) and tetrahydrocannabinol (THC), is cannabichromene (CBC) (including hemp flower strains). CBC can be found in cannabis and hemp strains from all over the world. Afghani, Pakistani, Lebanese, Iranian, Turkish, Mexican, Brazilian, Costa Rican, Jamaican, and South African cannabis types are all included. CBC Isolate is most plentiful in marijuana, but it can also be found in hemp. CBC, like CBD, is non-psychoactive and will not make you high on its own. When combined with THC, it may improve THC distribution to the brain.
What Are The Advantages Of Cannabidiol (CBC)?
Cannabichromene is not as plentiful as CBD and THC, although it, like CBG and other minor cannabinoids, can occur in lower amounts. As a result, obtaining Bulk CBC Isolate is an expensive process. The majority of studies on the advantages of CBC use a CBC isolate. This means that you would not experience these CBC benefits if you used a CBC-containing hemp strain. What this means is that you may feel some of these benefits in addition to the benefits of the other cannabinoids and terpenes present.
Antibacterial And Antifungal Properties
So, what are the advantages of CBC? CBC Wholesale contains anti-inflammatory, antibacterial, and antifungal effects, according to multiple research in animal models and lab experiments (in vitro). Researchers discovered that CBC was more effective than the conventional antibiotic streptomycin sulfate against B. subtilis, comparable to streptomycin sulfate against M. smegmatis, and very efficient against S. aureus as an antibacterial. Researchers discovered that CBC Wholesale showed better antifungal action against T. mentagrophytes than the commonly used antifungal medicine amphotericin B, and modest to moderate activity against C. Albicans and S. cerevisiae.
Analgesic And Anti-Inflammatory Properties
Cannabichromene’s anti-inflammatory activities are linked to some complex biological interactions. To summarize, CBC was found to drastically lower nitrite levels via activated immune cells known as macrophages. CBC is also hypothesized to prevent endocannabinoid inactivation by acting on the transient receptor potential ankyrin type 1 (TRPA1, an ion channel on cells that participates in inflammatory signaling). Inflammatory processes are inhibited as a result of all of these biological responses. The team that discovered this mechanism discovered that colitis was suppressed in their animal study.
Researchers have also discovered that CBC Wholesale has complicated interactions with the CB1 and CB2 receptors, as well as with THC. CBC Wholesale, like CBD, stimulates the endocannabinoid system by indirect pathways rather than directly through CB1 or CB2 receptors of the endocannabinoid system. In another mouse investigation, CBC was found to have analgesic (pain-relieving) properties. Interestingly, the researchers discovered that when CBC and THC were combined, the anti-inflammatory benefits were enhanced. They also discovered that CBC facilitated THC’s entry into the brain.
According to DeLong et al. (2010), “30 or 100 mg/kg CBC significantly increased THC levels in the brain but did not attain statistical significance in increasing THC blood levels (p0.07).” It is worth noting that when combined with the threshold dose of THC, these identical CBC doses showed heightened pharmacological effects.” Because of the entourage effect, the benefits of CBC can be improved by the addition of THC. It seems to reason that they complement one other because they occur naturally in some cannabis strains.
How Does Cannabichromene Work?
We discussed how CBC acts as an anti-inflammatory agent, but how does it affect our systems if it does not work through CB1 or CB2? According to Marcu, J. P. (2016), “CBC has been demonstrated to significantly interact with TRP cation channels such as TRPA1, TRPV1–4, and TRPV8.” According to Russo, E. B., and Marcu (2017), “CBC can interact with transient receptor potential (TRP) cation channels, inhibiting endocannabinoid inactivation and stimulating CB2 receptors… However, it has no substantial action at CB1 receptors…”
To clarify, “TRP cation channels” are channels found on the membrane surrounding an animal cell. These channels allow cations to enter the cell. Sodium, calcium, and magnesium are examples of cations. These cations serve as signals in the body, instructing various systems to turn on, turn off, release additional signals, or perform some other activity. In the case of CBC, the TRP channels respond to it by signaling alterations that excite the CB2 receptors.
As a result, CBC can have an effect on the endocannabinoid system without directly activating or deactivating cannabinoid receptors. Because TRP channels and the endocannabinoid system can both influence inflammation and pain responses in the body, it stands to reason that CBC can as well.
Dosage Of CBC
There is no standard or FDA-approved CBC dosage, however, the “lethal dose” of CBC is rather high. Orally administered CBC at doses up to 3000mg/kg/day resulted in no deaths. That amount proved deadly to several test animals when provided through injection. However, such a high dosage would be both impracticable and costly. For inflammation, CBC has reduced toxicity and can be used at higher doses than phenylbutazone (PBZ) or aspirin.
High CBC Cannabis Strains
Landrace strains from India are among the most naturally plentiful in cannabichromene. It is also discovered in larger concentrations in younger cannabis plants. Here are marijuana and hemp cannabis strains reported to be high in CBC:
- Three Kings
- Diesel that is sour
- Kush OG
- Genetics of headbands
- Sour Tsunami from Charlotte’s Web
- Lifter of the Sour
- Diesel from Durban
- Diesel Blueberry
- Hemp Flower Goliath
- Delight in the Netherlands Hemp Blossom
- HK Hemp Blossom
- Girl Guide Cookies Hemp Blossom
How Is CBC Isolate Created?
Cannabinoids in cannabis plants are acidic, which means they have not been “decarboxylated” to “activate.” In a living cannabis plant, cannabichromene appears as cannabichromene acid (CBCa). CBCa is created by combining the precursors’ geranyl pyrophosphate and olivetolic acid with the enzyme CBCA synthase. CBCa is decarboxylated to CBC over time or by heating over 200°F.
Bulk CBC Isolate is another product that is anticipated to enter the market soon, but now that you know more about how CBC works in your body, you may want to explore a high CBC hemp strain instead. This is because cannabinoids function best in groups. Individually, they each have some advantages, but when together in their natural state, they may function as nature intended. Because there has been a minimal human study on Bulk CBC Isolate and no clinical trials, no one can be assured of the long-term effects or overall effectiveness of CBC. It is, nevertheless, always fascinating to hear that cannabis is more than just CBD and THC. Other cannabinoids (and terpenes) like cannabichromene do play a significant role in the experience.